Byzantine-Robust Clustered Federated Learning

This paper focuses on the problem of adversarial attacks from Byzantine machines in a Federated Learning setting where non-Byzantine machines can be partitioned into disjoint clusters. In this setting, non-Byzantine machines in the same cluster have the same underlying data distribution, and different clusters of non-Byzantine machines have different learning tasks. Byzantine machines can adversarially attack any cluster and disturb the training process on clusters they attack. In the presence of Byzantine machines, the goal of our work is to identify cluster membership of non-Byzantine machines and optimize the models learned by each cluster. We adopt the Iterative Federated Clustering Algorithm (IFCA) framework of Ghosh et al. (2020) to alternatively estimate cluster membership and optimize models. In order to make this framework robust against adversarial attacks from Byzantine machines, we use coordinate-wise trimmed mean and coordinate-wise median aggregation methods used by Yin et al. (2018). Specifically, we propose a new Byzantine-Robust Iterative Federated Clustering Algorithm to improve on the results in Ghosh et al. (2019). We prove a convergence rate for this algorithm for strongly convex loss functions. We compare our convergence rate with the convergence rate of an existing algorithm, and we demonstrate the performance of our algorithm on simulated data

Antisense Oligonucleotides against miR-21 Inhibit the Growth and Metastasis of Colorectal Carcinoma via the DUSP8 Pathway

Accumulating research has documented that microRNA-21 (miR-21) plays an important role in the development of human colorectal carcinoma (CRC). Our recent work also showed that antisense oligonucleotides (ASOs) against miR-21 can impair the growth of CRC cells in vitro. However, the potential role of miR-21 in gene therapy against CRC remains to be fully elucidated. Here, we further observed the effect of ASOs against miR-21 on the growth and metastasis of CRC in vivo using a xenograft model of human CRC. We found that ASOs could effectively inhibit the growth and metastasis of CRC in vivo, accompanied by downregulated expression of miR-21 and reduced transduction of the AKT and ERK pathway. Mechanically, global gene expression analysis showed that the expression of DUSP8, a novel target of miR-21, was upregulated in tumor mass. Furthermore, overexpression of DUSP8 could remarkably suppress the proliferation and migration of CRC cells in vitro. Finally, downregulation of DUSP8 could abrogate the effects of ASOs against miR-21 on the proliferation and migration of CRC cells, as well as altered transduction of the AKT and ERK signaling pathway. Together, these data suggest that ASOs against miRNAs are an attractive and potential therapeutic for the treatment of human CRC and warrant further development. Keywords: miR-21, ASOs, colorectal carcinoma, growth, DUSP

Association of Maternal Dietary Patterns during Gestation and Offspring Neurodevelopment

The health effects of diet are long term and persistent. Few cohort studies have investigated the influence of maternal dietary patterns during different gestational periods on offspring’s health outcomes. This study investigated the associations between maternal dietary patterns in the mid- and late-gestation and infant’s neurodevelopment at 1 year of age in the Jiangsu Birth Cohort (JBC) Study. A total of 1178 mother–child pairs were available for analysis. A semiquantitative food frequency questionnaire (FFQ) was used to investigate dietary intake at 22–26 and 30–34 gestational weeks (GWs). Neurodevelopment of children aged 1 year old was assessed using Bayley-Ⅲ Screening Test. Principal component analysis (PCA) and Poisson regression were used to extract dietary patterns and to investigate the association between dietary patterns and infant neurodevelopment. After adjusting for potential confounders, the maternal ‘Aquatic products, Fresh vegetables and Homonemeae’ pattern in the second trimester was associated with a lower risk of being non-competent in cognitive and gross motor development, respectively (cognition: aRR = 0.84; 95% CI 0.74–0.94; gross motor: aRR = 0.80; 95% CI 0.71–0.91), and the similar pattern, ‘Aquatic products and Homonemeae’, in the third trimester also showed significant association with decreased risk of failing age-appreciate cognitive and receptive communication development (cognition: aRR = 0.89; 95% CI 0.80–0.98; receptive communication: aRR = 0.91; 95% CI 0.84–0.99). Notably, adherence to the dietary pattern with relatively high aquatic and homonemeae products in both trimesters demonstrated remarkable protective effects on child neurodevelopment with the risk of being non-competent in cognitive and gross motor development decreasing by 59% (95% CI 0.21–0.79) and 63% (95% CI 0.18–0.77), respectively. Our findings suggested that adherence to the ‘Aquatic products and Homonemeae’ dietary pattern during pregnancy may have optimal effects on offspring’s neurodevelopment

Data_Sheet_1_Associations of maternal dietary patterns during pregnancy and fetal intrauterine development.docx

Dietary pattern is excellent in reflecting an individual's eating conditions. Longitudinal data on fetal growth can reflect the process of intrauterine growth. We aimed to evaluate the associations between maternal dietary patterns and intrauterine parameters in middle and late pregnancy. The present study was conducted within Jiangsu Birth Cohort (JBC) study. Dietary information was assessed with a food frequency questionnaire (FFQ) in the second and third trimester of gestation. B-ultrasound scans were performed to obtain fetal intrauterine parameters, including head circumference (HC), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW). Exploratory factor analysis was used to extract dietary patterns. Multiple linear regression and linear mixed-effects model (LMM) were used to investigate the association between maternal dietary patterns and fetal growth. A total of 1,936 pregnant women were eligible for the study. We observed inverse associations of maternal “Vegetables and fish” and “Snack and less eggs” patterns during mid-pregnancy with fetal HC Z-score, respectively (“Vegetables and fish”: β = −0.09, 95% CI −0.12, −0.06; “Snack and less eggs”: β = −0.05, 95% CI −0.08, −0.02). On the contrary, “Animal internal organs, thallophyte and shellfish” pattern in the second trimester was associated with increased HC Z-scores (β = 0.04, 95% CI 0.02, 0.06). Consistently, score increase in “Vegetables and fish” pattern in the third trimester was inversely associated with the Z-scores of HC (β = −0.05, 95% CI −0.09, −0.02), while “Meat and less nuts” pattern was positively correlated with the Z-scores of HC (β = 0.04, 95% CI 0.02, 0.07). As compared to the fetus whose mothers at the lowest tertile of “Snack and less eggs” pattern in both trimesters, those whose mothers at the highest tertile demonstrated 1.08 fold (RR = 2.10, 95% CI 1.34–3.28) increased risk of small HC for gestational age (GA). No correlation was observed between maternal dietary patterns and other intrauterine parameters. Our results suggested the effects of maternal dietary patterns on fetal growth, particularly HC. These findings highlighted the adverse impact of unhealthy dietary pattern on fetal growth, might provide evidence for strategies to prevent intrauterine dysplasia and dietary guidelines during pregnancy.</p